Resources
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Roadmap for the European Virtual Human Twin
The VHT roadmap provides a comprehensive framework and set of recommendations for stakeholders to effectively contribute to the development and implementation of this transformative technology. Embracing the principles outlined in this roadmap will pave the way for a future where healthcare is personalized, predictive, and participatory, leading to improved health outcomes for all.
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The In Silico Medicine Info Kit
Meaningful innovation in in silico medicine depends on engaging society’s perspectives and insights. VPH has gathered extensive experience through its participation in EU-funded projects such as SimCardioTest, SimCor, In Silico World, REALM, and EDITH-CSA.
These learnings are now available in the In Silico Medicine Info Kit — a free, practical resource to help researchers and project managers plan and implement effective stakeholder engagement.
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Roadmaps
2025
- Building the European Virtual Human Twin (EDITH CSA; 2022-2024, 101083771)
2015
- In silico Clinical Trials: How Computer Simulation will Transform the Biomedical Industry (Avicenna CSA; 2013-2015, 611819)
2013
- Digital patient roadmap (Discipulus CSA; 2011-2013, 288143)
2007
- Seeding the EuroPhysiome: A Roadmap to the Virtual Physiological Human (STEP CSA; 2005- 2006, 027642)
Books
2024
- Viceconti, Marco and Emili, Luca. Toward good simulation practice: best practices for the use of computational modelling and simulation in the regulatory process of biomedical products. Springer Nature, 2024.
- Rangarajan, J. R., et al. The In Silico Medicine Info Kit. Zenodo, 2024.
Publications
2024
- Elhadj, Elisa, et al. “Brokering responsible research and innovation in in silico medicine.” Journal of Responsible Innovation 11.1 (2024): 2414484.
2023
- Lesage, Raphaëlle, et al. “Mapping the use of computational modelling and simulation in clinics: A survey“. Frontiers in Medical Technology 5 (2023): 1125524.
- Viceconti, Marco, et al. “Position paper from the digital twins in healthcare to the virtual human twin: a moon-shot project for digital health research“. IEEE Journal of Biomedical and Health Informatics 28.1 (2023): 491-501.
2022
- Pappalardo, Francesco, et al. “Toward a regulatory pathway for the use of in silico trials in the CE marking of medical devices“. IEEE Journal of Biomedical and Health Informatics 26.11 (2022): 5282-5286.
2021
- Musuamba, Flora T., et al. “Scientific and regulatory evaluation of mechanistic in silico drug and disease models in drug development: Building model credibility“. CPT: Pharmacometrics & Systems Pharmacology 10.8 (2021): 804-825.
2020
- Musuamba, Flora T., et al. “Verifying and validating quantitative systems pharmacology and in silico models in drug development: current needs, gaps, and challenges“. CPT: Pharmacometrics & Systems Pharmacology 9.4 (2020): 195.
Position papers
2024
- Geris, Liesbet, et al. Policy brief: Accelerating the uptake of in silico trials in healthcare. Zenodo.
2023
- Shiny, Martis B, et al. The potential of in silico approaches to streamline drug development
2022
- Geris, Liesbet, et al. WHITE PAPER: the role of Artificial Intelligence within in silico medicine. Zenodo.
Public consultations
2025
- Call for evidence on the future of EU Medical Device Regulation: Call | Feedback from VPH
- EMA concept paper on guideline on assessment and reporting of mechanistic models used in the context of model informed drug development: Call | Feedback from VPH
- VPH contributes to the European Commission’s consultation on the Medical Device Regulation: Call | Contribution by VPH
2022
- US. FDA Guideline on FDA’s Draft Guidance: “Credibility of Computational Modeling and Simulation in Medical Device Submissions”: Call | Comment from In Silico World | Comment from SIMCor